![]() ![]() monandra is effective as an antidote for treating HIT. ![]() The results from this study show that leaf methanolic extract of B. Heparins, including unfractionated heparin and a variety of low molecular weight (LMW) heparin products, are used extensively as anticoagulants. Acute toxicity test showed no significant physical and behavioral changes. safely and completely reverses the anticoagulant effects of low molecular weight heparin. It also significantly decreased the bleeding and clotting time. idarucizumab, a drug-specific antidote andexanet alfa, a. wt had significantly (P < 0.05) higher platelet counts (225.10 ± 6.41) than the control groups: normal control (181.90 ± 11.38) and positive control (127.65 ± 5.79). This study showed that the mice in the group treated with methanolic leaf extract of B. Bleeding time and clotting time were also determined. Furthermore, blood samples were collected to determine the blood platelet count. Maintenance dose: 20,000 to 40,000 units per 24 hours by continuous IV infusion. monandra at a dose of 100, 200, and 400 mg/kg body weight (b. Usual Adult Dose for Deep Vein Thrombosis. Groups III, IV, and V (treatment groups) were given heparin and methanolic leaf extract of B. Group I (normal control) was given distilled water only, and Group II (positive control) was given heparin only. The mice were divided into five Groups (I–V) of six mice each. ![]() A total of 30 mice were used for the experimental study. The aim of the study was to determine the effect of methanolic leaf extract of Bauhinia monandra as a potential antidote for treating heparin-induced thrombocytopenia (HIT). Currently, chemical compounds for managing thrombocytopenia are needed. Question: 1- The antidote for heparin is : a) protamine sulfate b) aspirin c) enoxaparin d) vitamin K 2- The order is to give aminophylline 20mg/hr. Globally, thrombocytopenic cases in hospitals leading to 80% of deaths are mainly due to refractory bleeding and lack of availability of platelet concentrates. Thrombocytopenia is closely associated with heparin therapy and hematological disorders and other common diseases in patients admitted in the hospital. ![]()
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